報告人：嚴軍　博士生導師，研究員

報告人介紹：

1998-2003   美國紐約大學物理系   博士
2003-2006   美國阿拉斯加大學   博士后

2006-2015  中科院－德國馬普學會計算生物學研究所 研究員
2015-至今     中科院上海生科院神經(jīng)科學研究所   研究員

主要研究工作內(nèi)容：

1.全腦介觀腦圖譜、神經(jīng)元全腦投射圖譜的重建與分析；

 2.采用計算生物學、生物信息學、系統(tǒng)生物學的方法，針對小鼠、斑馬魚等模式生物開展生物節(jié)律神經(jīng)網(wǎng)絡、基因調(diào)控網(wǎng)絡的研究。

代表性論文(*通訊作者)：  

1.Fan, Z., Zhao,  M., Joshi, P., Li, P., Zhang, Y., Guo, W., Xu, Y., Wang, H., Zhao, Z., Yan, J.  (2017) A class of circadian long non-coding RNAs mark enhancers modulating  long-range circadian gene regulation. Nucleic. Acids. Res. doi:  10.1093/nar/gkx156

2.Xu, Y., Guo, W.,  Li, P., Zhang, Y., Zhao, M., Fan, Z., Zhao, Z., Yan, J. (2016) Long-range  chromosome interactions mediated by cohesin shape circadian gene expression.  PLOS Genetics 10.1371

3.Li, Y., Li, G.,  G?rling, B., Luy, B., Du, J., and Yan, J. (2015) Integrative Analysis of  Circadian Transcriptome and Metabolic Network Reveals the Role of de novo Purine  Synthesis in Circadian Control of Cell Cycle. PLoS computational biology. 11(2):  e1004086.

4.Liu, J., Wang,  X., Li, J., Wang, H., Wei, G., Yan, J. (2014) Reconstruction of the Gene  Regulatory Network Involved in the Sonic Hedgehog Pathway with a Potential Role  in Early Development of the Mouse Brain. PLoS computational biology.  10(10):e1003884.

5.Liu, Y., Hu, W.,  Murakawa, Y., Yin, J., Wang, G., Landthaler, M., and Yan, J. (2013).  Cold-induced RNA-binding proteins regulate circadian gene expression by  controlling alternative polyadenylation. Scientific reports 3, 2054.

6.Li, Y., Li, G.,  Wang, H., Du, J., and Yan, J. (2013). Analysis of a gene regulatory cascade  mediating circadian rhythm in zebrafish.PLoS computational biology 9,  e1002940.

7.Wang, H., Liu,  Y., Briesemann, M., and Yan, J. (2010).Computational Analysis of Gene  Regulations in Animal Sleep Deprivation.Physiol Genomics 42,  427-436.

8.Shao, C., Liu,  Y., Ruan, H., Li, Y., Wang, H., Kohl, F., Goropashnaya, A.V., Fedorov, V.B.,  Zeng, R., Barnes, B.M., Yan, J. (2010).Shotgun proteomics analysis of  hibernating arctic ground squirrels.Mol Cell Proteomics 9, 313-326.

9.Yan, J., Wang,  H., Liu, Y., and Shao, C. (2008). Analysis of gene regulatory networks in the  mammalian circadian rhythm.PLoS computational biology 4, e1000193..

報告二題目：感知與抉擇的神經(jīng)環(huán)路運算

報告人：徐寧龍　博士生導師，研究員

報告人介紹：

1999-2006   中國科學院神經(jīng)科學研究所   博士
2006-2008   美國冷泉港實驗室   博士后

2008-2013   美國 HHMI Janelia Research Campus 博士后

2013-至今     中科院上海生科院神經(jīng)科學研究所   研究員

主要研究方向：

  1.  我們在執(zhí)行聽覺感知抉擇任務的小鼠中，使用雙光子顯微鏡觀察大腦皮及皮層下神經(jīng)元的電信號，以揭示聽覺感知與行為抉擇的神經(jīng)編碼原理；

2.  我們使用光遺傳學和化學遺傳學等神經(jīng)環(huán)路干預技術，揭示各個腦區(qū)及它們之間形成的環(huán)路在感知與抉擇中的作用機制；

3.  我們與人工智能研究人員合作，探索如何將動物面對復雜感覺信息進行行為抉擇的神經(jīng)計算原理應用于機器智能技術開發(fā)。

代表成果

1. Wang Z, Xu NL, Wu CP, Duan S*, and  Poo MM*, Bidirectional changes in spatial dendritic integration accompanying  long-term synaptic modifications. Neuron, 37: 463-72  (2003).

2. Xu NL, Ye CQ, Zhang XH*, and Poo  MM*, Coincidence detection of synaptic inputs is facilitated at the distal  dendrites after long-term potentiation induction. J. Neurosci., 26: 3002-3009  (2006).

3. Xu NL, Harnett MT,  O’Connor DH, Huber D, Williams SR, Svoboda K., Magee JC*,  Nonlinear dendritic integration of sensory and motor input during an active  sensing task. Nature, 492: 247-251 (2012).

4. Petreanu L, Gutnisky DA, Huber D,  Xu NL, O’Connor DH, Tian L, Looger L, and Svoboda K*,  Activity in motor-sensory projections reveals distributed coding in  somatosensation. Nature, 489: 299–303  (2012).

5. Harnett MT, Xu NL, Magee JC*,  Williams SR*, Potassium Channels Control the Interaction between Active  Dendritic Integration Compartments in Layer 5 Cortical Pyramidal Neurons.  Neuron, 79: 516-529 (2013).

6. Chen JL*, Andermann ML, Keck T, Xu  NL, and Ziv Y, Imaging Neuronal Populations in Behaving Rodents: Paradigms for  Studying Neural Circuits Underlying Behavior in the Mammalian Cortex. J.  Neurosci., 33(45): 17631-17640 (2013).

7. Guo ZV, Hires SA, Li N, O'Connor  DH, Komiyama T, Ophir E, Huber D, Bonardi C, Morandell K, Gutnisky D, Peron S,  Xu NL, Cox J, Svoboda K*, Procedures for Behavioral Experiments in Head-Fixed  Mice. PLoS ONE , 9, e88678 (2014).

時間：2018年4月25日下午6：00

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